rifampin will reduce the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.apalutamide will reduce the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4
Serum concentrations of modafinil may be decreased to some clinically sizeable extent while in the presence of medicine that induce CYP3A4. These contain rifampin, phenytoin, St.FDA is proposing to amend its polices so as to add two lists pinpointing drug products or categories of drug products which existing demonstrable challenges for compounding
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